CIS

Clinical Immunology Society (CIS)

2017 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

*The Final Program is Now Available*

Thursday, March 23

4:30 pm - 4:40 pm Welcome from CIS President
Jordan Orange, MD, PhD

Baylor College of Medicine
4:40 pm – 6:00 pm CIS Fellowship Grantee Presentations

Moderator:
Jordan Orange, MD, PhD
Baylor College of Medicine

Revealing the Role of Human IgA in Gut Homeostasis
Jared Silver, MD, PhD
Brigham and Women's Hospital

Using Persistent Cutaneous Viral Infections to Uncover Novel Immune Dysfunction
Sarah Henrickson, MD, PhD
The Children's Hospital of Philadelphia

Oral Abstract
SUCCESSFUL CLINICAL STUDY OF LENIOLISIB (CDZ173), A SMALL MOLECULE PI3K-DELTA INHIBITOR, IN PATIENTS WITH APDS/PASLI
V. Koneti Rao, MD
NIAID/NIH
6:00 pm – 7:00 pm Robert A. Good Lecture
1 AMA PRA Category 1 Credits™

Moderator:

Jordan Orange, MD, PhD
Baylor College of Medicine

Newborn Screening for PID - and Beyond
Speaker: Lennart Hammarström, MD, PhD
Karolinska Institutet
7:00 pm – 8:30 pm Corporate Sponsored Dinner Symposium
Topic: Navigating through the Diagnostic and Treatment Controversies in Specific Antibody Deficiency: US and European perspectives and recommendations

(Free; Separate Registration Required)

Friday, March 24

7:00 am - 8:00 am Breakfast
8:00 am - 9:30 am Plenary Session: Next Generation Genomics in This Generation
1.5 AMA PRA Category 1 Credits™

Speakers:
Technologies Around Genomics
Brendan Lee, MD, PhD
Baylor College of Medicine

Understanding the Shared Genetic Architecture of Autoimmune and Inflammatory Disorders: Implications on Mechanism and Clinical Translation
Charlly Kao, PhD
Children's Hospital of Philadelphia

21st Century Genomic Advances for Clinicians
Isabelle Meyts, MD, PhD
University Hospitals Leuven

Oral Abstract
NUCLEASE-TARGETED GENE-EDITING TO ACHIEVE STABLE FOXP3 EXPRESSION IN PRIMARY HUMAN T CELLS DELAYS THE ONSET XENOGENEIC MODEL OF GRAFT-VERSUS-HOST DISEASE (GVHD)
Yufei Xiang, MD, PhD
Seattle Children's Research Institute
 
9:30 am - 10:00 am Morning Break
10:00 am - 11:00 am

Guided Poster Session #1

Group 1

Moderators:
Jolan Walter, MD, PhD, Johns Hopkins All Children's Hospital
Artemio Jongco, MPH, MD, PHD, Feinstein Institute for Medical Research

COMBINED IMMUNODEFICIENCY AND EPSTEIN-BARR VIRUS-INDUCED B CELL MALIGNANCY IN HUMANS WITH INHERITED CD70 DEFICIENCY
Huei Jing, PhD
NIAID, NIH

EVALUATION OF TROUGH LEVELS OF ANTIBODIES TO 12 SEROTYPES OF S. PNEUMONIA IN A PHASE III CLINICAL TRIAL IN PATIENTS WITH PRIMARY IMMUNODEFICIENCY (PID)
Troy R. Torgerson, MD, PhD
Seattle Children's Research Institute

HEMATOPOIETIC STEM CELL TRANSPLANTATION RESCUES THE VASCULAR, HAEMATOLOGICAL AND IMMUNOLOGICAL PHENOTYPE IN ADENOSINE DEAMINASE 2 DEFICIENCY
Isabelle Meyts, MD, PhD
University Hospitals Leuven

LONG TERM PROGNOSIS IN AUTOSOMAL DOMINANT HYPER IgE SYNDROME
Amanda K. Urban, CRNP
Leidos Biomedical Research

A MOUSE MODEL OF TYPE 1 KABUKI SYNDROME WITH DEFECTIVE HUMORAL RESPONSES TO MUCOSAL VACCINATION
Tareian A. Cazares, MS
Cincinnati Children's Hospital Medical Center

Group 2

Moderators:
Lisa Kobrynski, MD, MPH, Emory University
Jennifer Leiding, MD, University of South Florida

EFFICACY OF THE JAK INHIBITOR RUXOLITINIB IN TWO PATIENTS WITH SAVI SYNDROME
Stefano Volpi, MD, PhD
Istituto Giannina Gaslini

MASS MINING: A CROWDSOURCING APPROACH FOR META-ANALYZING GENE EXPRESSION SIGNATURES OF AUTOIMMUNITY USING LARGE-SCALE PUBLIC DATA SETS
Rachel Sparks, MD, MPH
National Institute of Allergy and Infectious Diseases, NIH

SAFETY AND EFFICACY OF GENE THERAPY USING A MODIFIED SELF-INACTIVATING GAMMARETROVIRAL VECTOR FOR SCID-X1
Sung-Yun Pai, MD
Boston Children's Hospital

SIBLINGS WITH FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS TYPE 5 IN ASSOCIATION WITH SEVERE ENTEROPATHY: MANAGEMENT DILEMMAS
Roxane Labrosse, MD
CHU Sainte-Justine, University of Montreal

A LINEAR DISCRIMINANT MODEL TO PREDICT A CLINICAL DIAGNOSIS OF PRIMARY IMMUNODEFICIENCY        
Saul Oswaldo Lugo-Reyes, MD, MS
National Institute of Pediatrics

11:00 am - 12:30 pm Plenary Session: Immunological Lessons Learned from PIDs
1.5 AMA PRA Category 1 Credits™

Moderators:

Manish Butte, MD, PhD,
University of California-Los Angeles
Monica Lawrence, MD
University of Virginia

Speakers:
B Cell Tolerance Mechanisms and Defects in PIDs
Neil Romberg, MD
University of Pennsylvania

Conventional T Cell Subsets
Stuart Tangye, PhD
Garvan Institute of Medical Research

Dendritic Cell Biology
Venetia Bigley, MB, BChir, PhD, MRCP, FRCPath
Newcastle University

Oral Abstracts:
MUTATIONS IN THE TYROSINE-PROTEIN KINASE LYN CAUSE AN EARLY-ONSET NEUTROPHILIC VASCULITIS SYNDROME
Adriana A. Jesus, MD, PhD
National Institutes of Health

MUTATIONS IN THE H+-ATPASE SUBUNIT ATP6V0A2 ASSOCIATED WITH CUTIS LAXA ALSO CAUSE NK CELL DEFICIENCY
Levi B. Watkin, PhD
Baylor College of Medicine
12:30 pm - 2:00 pm Lunch/Exhibit Hall Open
1:30 pm - 2:00 pm Poster Viewing/Exhibit Hall Open
2:00 pm - 3:30 pm

Plenary Session: The "Ome" and "Omics"
1.5 AMA PRA Category 1 Credits™

Moderators:
Sergio Rosenzweig, MD, PhD
NIAID/NIH
Elena Hsieh, MD
University of Colorado, Denver

Speakers:
Systems Genomics and Systems Immunology
John Tsang, PhD
NIAID, NIH

Transcriptome of Human Treg Subsets
Daniel Campell, PhD
Benaroya Research Institute

A New Genetic Etiology of Inherited NK Cell Deficiency
Emmanuelle Jouanguy, PhD,
INSERM/Université Paris Descartes

Oral Abstract:
DRIED BLOOD SPOTS FOR GENE SEQUENCING: TRAVELING ON LOW BUDGET!
Gesmar Segundo, MD, PhD
Seattle Children's Research Institute, Federal University of Uberlandia

3:30 pm - 4:00 pm Afternoon Break
4:00 pm - 5:00 pm

The CIS Fahey/Rose Founders Lecture
1 AMA PRA Category 1 Credits™

Moderators:
Joyce Yu, MD
Morgan Stanley Children's Hospital/Columbia University Medical Center
Hans Ochs, MD
University of Washington

Speaker:
Translating Immunological Advances Into Solutions for Global Health Problems
Chris Wilson, MD

5:00 pm - 5:30 pm DAIT/NIAID funding opportunities for PID

Speaker: Frosso Voulgaropoulou, PhD
AMIB, DAIT, NIAID, NIH
5:30 pm - 6:00 pm CIS Annual Business Meeting

Saturday, March 25

7:00 am - 8:00 am Breakfast
8:00 am - 9:30 am Plenary Session: Immune Regulation
1.5 AMA PRA Category 1 Credits™

Moderators:
Thomas Fleisher, MD
NIH Clinical Center
Joud Hajjar, MD
Baylor College of Medicine

Speakers:
Formation of Immunological Memory in Complex Infections
Marion Pepper, PhD
University of Washington

The Deficiency of Adenosine Deaminase 2--A Master of Disguise
Amanda Ombrello, MD
NHGRI, NIH

Manipulating Regulatory T Cells to Restore Tolerance
Talal Chatila, MD
Boston's Children's Hospital

Oral Abstracts:
VERY EARLY ONSET IBD-THE SEARCH FOR MONOGENIC CAUSES
Kathleen Sullivan, MD, PhD
Children's Hospital of Philadelphia

AN INHERITED SYNDROME OF AUTOIMMUNITY ASSOCIATED WITH CD40LG DUPLICATION
Carole Le Coz, PhD
Children's Hospital of Philadelphia
9:30 am - 10:00 am Morning Break
10:00 am - 11:00 am Guided Poster Session #2

Group 1


Moderators:
Jack Bleesing, MD, PhD, Cincinnati Children's Hospital
Zeynep Yesim Kucuk, MD, Cincinnati Children's Hospital

LIVER ABNORMALITIES IN DOCK8 DEFICIENCY
Anahita Agharahimi, CRNP
NIAID/NIH

HUMAN CD40L DEFICIENCY DYSREGULATES THE MACROPHAGE TRANSCRIPTOME CAUSING FUNCTIONAL DEFECTS THAT ARE IMPROVED BY EXOGENOUS IFN-γ
Octavio Cabral-Marques, MSc
Institute of Biomedical Sciences-University of Sao Paulo

PATIENTS WITH XIAP DEFICIENCY HAVE CIRCULATING FREE IL-18 WHICH MAY REPRESENT A THERAPEUTIC TARGET

Rebecca Marsh, MD
Cincinnati Children's Hospital Medical Center

REDUCED TOXICITY ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION WITH BUSULFAN, FLUDARABINE AND ALEMTUZUMAB: A PROMISING APPROACH FOR PRIMARY IMMUNE DEFICIENCIES REQUIRING MYELOABLATIVE HCT?
Sharat Chandra, MD, MRCPCH
Cincinnati Children's Hospital Medical Center

CHROMIUM RELEASE NATURAL KILLER CELL CYTOTOXICITY HAS POOR DIAGNOSTIC ACCURACY COMPARED TO FLOW CYTOMETRIC PERFORIN AND CD107a TESTING FOR DETECTION OF PATIENTS WITH FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Tamar S. Rubin, MD
University of Alberta

Group 2

Moderators:
Megan A. Cooper, MD, PhD, Washington University, St. Louis
David Hagin, MD, PhD, Tel-Aviv Sourasky Medical Center

VEDOLIZUMAB IN CHRONIC GRANULOMATOUS DISEASE: A SAFE AND PROMISING BRIDGE THERAPY FOR CGD RELATED COLITIS
Christa S. Zerba, MD
NIAID/NIH

GERMLINE HYPOMORPHIC, DOMINANT NEGATIVE CARD11 MUTATIONS IN SEVERE ATOPIC DISEASE
Andrew L. Snow, PhD
Uniformed Services University of the Health Sciences

SEVERE COMBINED IMMUNODEFICIENCY CAUSED BY THYMIC APLASIA DUE TO FAMILIAL MUTATION IN TBX1
David S. Lindsay, MD
University of South Florida

VILLOUS ATROPHY IS THE HALLMARK OF LONG TERM SURVIVAL IN CHRONIC NOROVIRUS INFECTION
Avni Y. Joshi, MD, MS
Mayo Clinic

ROLE OF GUT MICROBIOTA TO MONITOR IMMUNE DYSREGULATION IN CONGENITAL IMMUNE DYSREGULATION SYNDROMES
Eleonora Gambinieri, MD
University of Florence
 
11:00 am - 12:30 pm Plenary Session: Hematopoietic Cell Transplantation and Immune Reconstitution
1.5 AMA PRA Category 1 Credits™

Moderators:
Shanmuganathan Chandrakasan, MD
Emory University School of Medicine, Children's Healthcare of Atlanta
László Maródi, MD
University of Debrecen, Medical and Health Science Center

Speakers:
New Approaches to Hematopoietic Cell Transplantation
Brenda Sandmaier, MD
Fred Hutchinson Cancer Research Center

Immune Reconstitution in Hematopoietic Cell Transplantation
Jan Storek, MD, PhD
University of Calgary

Hematopoietic Cell Transplantation for PIDs: The Indian Experience
Revathi Raj, MD
Apollo Hospitals

Hematopoietic Transplantation: Thinking Outside the Box
Andrew Cant, BSc, MD, FRCP, FRCPCH
Newcastle General Hospital

Oral Abstract:

WISKOTT-ALDRICH SYNDROME: AN INTERNATIONAL STUDY ANALYZING THE IMPACT OF TREATMENT DECISIONS ON FREQUENCY OF DISEASE-RELATED COMPLICATIONS AND PHYSICIAN-PERCEIVED QUALITY OF LIFE
Michael H. Albert, MD
Dr. von Haunder University Children's Hospital
 
12:30 pm - 2:00 pm Lunch/Exhibit Hall Open
1:30 pm - 2:00 pm Poster Viewing/Exhibit Hall Open
2:00 pm - 3:30 pm Tales from the Listserv
1.5 AMA PRA Category 1 Credits™

Moderators:
Eric Allenspach, MD, PhD
University of Washington & Seattle Children's Hospital
Elie Haddad, MD, PhD
CHU Ste-Justine, University of Montreal
Mikko Seppänen, MD, PhD
Helsinki University Central Hospital

Mystery Case #1
Megan A. Cooper, MD, Washington University in St. Louis

Mystery Case #2
Benjamin Wright, MD, Mayo Clinic

Mystery Case #3
Luis Ignacio Gonzalez-Granado, MD, Hospital Universitario Doce de Octubre

3:30 pm - 4:00 pm Afternoon Break
4:00 pm - 4:20pm Presidential Award Lecture

Speaker: Charlotte Cunningham-Rundles, MD, PhD
Mt. Sinai Medical Center
4:20 pm - 5:00 pm

Richard Schiff Lecture
1 AMA PRA Category 1 Credits™

Moderators:
Antonio Condino-Neto, MD, PhD
University of Sao Paulo
Andrew L. Snow, PhD
Uniformed Services University of the Health Sciences

Combinatorial Approaches to Understand Autoimmune Risk: Mechanistic Insight from Immunodeficiency and GWAS
Speaker: David Rawlings, MD
Seattle Children's Research Institute

Sponsored by an unrestricted educational grant from Shire
 

5:00 pm - 7:00 pm Closing Reception

Sunday, March 26

7:00 am - 8:00 am Breakfast
8:00 am - 10:00 am Plenary Session: Hot New Defects in Primary Immunodeficiencies
2 AMA PRA Category 1 Credits™

Moderators:
Maite de la Morena, MD
University of Texas Southwestern
Lisa Forbes, MD
Baylor College of Medicine

Speakers:
A New Syndromic Defect Associated with Thymic Dysfunction and SCID
Luigi Notarangelo, MD
NIAID, NIH

New Genetic NKD
Jordan Orange, MD, PhD
Baylor College of Medicine

Hoffman Syndrome
Lori Broderick, MD, PhD
University of California, San Diego

Human MDA5 Deficiency Confers Susceptibility to Human Rhinovirus If
Helen Su, MD, PhD
NIAID, NIH

Inherited Human ZNF341 Deficiency Underlies Candidiasis and Allergy
Anne Puel, PhD
INSERM/Université Paris Descartes

Oral Abstracts:
RPSA MUTATIONS IN ISOLATED CONGENITAL ASPLENIA (ICA): A RIBOSOMOPATHY UNVEILED
Barbara Bosch, MD
The Rockefeller University

THE ZINC-FINGER-TRANSCRIPTION-FACTOR ZNF341 DEFICIENCY IN 3 SISTERS
Sara Sebnem Kilic, MD
Uluda─č University Medical Faculty
 
10:00 am - 10:15 am Break
10:15 am - 12:00 pm Plenary Session: Clinical Management Conundrums in PIDs
2 AMA PRA Category 1 Credits™

Moderators:
Steven Holland, MD
NIAID, NIH
Nicholas Rider, DO
Baylor College of Medicine

Speakers:
Hematopoietic Cell Transplantation for PIDs
Lauri Burroughs, MD
Fred Hutchinson Cancer Research Center & University of Washington

Autoimmune Cytopenias in PIDs
Markus Seidel, MD
Medical University of Graz

Opportunities and Challenges in Anti-Tumor Immune Reconstitution With CAR T Cells
Michael Jensen, MD
University of Washington School of Medicine & Seattle Children's Research Institute

IBD in PIDs
Troy Torgerson, MD, PhD
University of Washington & Seattle Children's Research Institute

Respiratory Papillomatosis
Vincent Bonagura, MD
Alexandra & Steven Cohen Children's Medical Center