CIS 2011 Annual Meeting, May 19-22, 2011, Chicago, IL

CIS Annual Meeting - The Science and Practice of Human Immunology

2011 Annual Meeting Final Agenda

Wednesday, May 18
7:00 pm - 8:00 pm Advanced PID School Opening Lecture
8:00 pm - 9:30 pm Advanced PID School Opening Reception

Thursday, May 19
8:30 am - 5:30 pm Advanced PID School
6:00 pm - 7:00 pm The All Children's, St. Petersburg Robert A. Good Memorial Lecture
Evolution of the Adaptive Immune Response
Max Cooper, MD
Emory University

Credit: 1 CME
Upon completion of this session, participants should be able to: understand key similarities and strikingly parallels between the adaptive immune system in primitive jawless vertebrates (lampreys) and higher vertebrates; become familiar with a new type of monoclonal antibodies and their potential use in immunodiagnostic tests; and review flow cytometry as a diagnostic tool in characterization of normal and malignant cells.
7:00 pm - 9:00 pm Poster Reception & Annual Meeting Opening Reception

Supported in part by Kronus

Friday, May 20
7:30 am - 8:30 am Breakfast
8:30 am - 10:45 am The Micro Session: How Small Can You Go?

Credit: 2.25 CME
Upon completion of this session, participants should be able to: provide an understanding of the role of microRNA in control of gene expression; and provide evidence of the function of microRNAs in the pathophysiology of Juvenile dermatomyositis
8:30am - 9:00am MicroRNAs and Immune Control
Carlo Croce, MD
Ohio State University
9:00am - 9:30am Microbiome
Fredrick Bushman, PhD
University of Pennsylvania
9:30am - 10:00am Microbe Hunting
W. Ian Lipkin, MD
Columbia University
10:00am - 10:15am Pathophysiology of Untreated Juvenile Dermatomyositis Muscle: Hypoxia and Apoptosis are Regulated by MicroRNA's
Simone Treiger Sredni, MD, PhD
Children's Memorial Hospital
10:15am - 10:30am Advantages of Helminth Conditioning over Therapeutic Antibody in Treatment of IBD
Ahmed Metwali, PhD
University of Iowa College of Medicine
10:30am - 10:45am Adenovirus PCR-positivity in Stool Precedes Intestinal Graft Versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
L. Schulz, BSc
University Medical Center / Wilhelmina Children's Hospital
10:45 am - 11:00 am Break
11:00 am - 12:30 pm Medical Crossfire: Comparing Routes of IgG Administration for Primary Immunodeficiency Disorders
Credit: 1.5 CME
CME sponsorship of this symposium is by InforMEDical Communications, Inc., which is accredited by the ACCME to provide continuing medical education for physicians.  To receive credit, participants must register, attend the symposium, correctly answer 7 of 10 post-test questions, and complete a program assessment.  A certificate of completion will be delivered within 2 weeks.

Learning Objectives
Following participation you should be able to:
  • Discuss clinical guidance for the use of IVIG and SCIG
  • Discuss tolerability and adverse event management for IVIG and SCIG 
  • Assess pharmacokinetic benefits of IVIG and SCIG

Agenda

Overview of Current Routes of IgG Administration
Troy Torgerson, MD, PhD (Chair)
Assistant Professor, Pediatric Immunology/Rheumatology
University of Washington, Department of Pediatrics
Co-Director, Immunology Diagnostic Laboratory
Center for Immunity and Immunotherapies
Seattle Children's Research Institute

Why I Use IVIG
Vincent R. Bonagura, MD
Chief, Allergy/Immunology
Cohen Children's Medical Center of New York
North Shore-Long Island Jewish Health System
Associate Chair, Pediatrics
Professor of Pediatrics, Microbiology, and Immunology
Albert Einstein College of Medicine

Why I Use SCIG
Ralph S. Shapiro, MD
Director
Midwest Immunology Clinic
Plymouth, Minnesota

Expert Debate and Q&A
Moderator: Troy Torgerson, MD, PhD

Sponsored by InforMEDical Communications, Inc
Supported by an educational grant from
Baxter
12:30 pm - 1:30 pm Lunch Break
1:30 pm - 3:00 pm Primary Immunodeficiency - Evolving Concepts in the Diagnosis and Treatment

Speaker
Jordan Orange MD, PhD
Associate Professor of Pediatrics
University of Pennsylvania School of Medicine
Children's Hospital of Philadelphia, Division of Immunology
3615 Civic Center Blvd, ARC-907A
Philadelphia, PA 19104

Topics of Discussion:
  1. Recent genomic advances in antibody deficiencies
  2. Widescale use of genetically oriented screening approaches for combined immune deficiency
  3. Optimizing therapy for antibody-deficient patients and considerations specific to intravenous and subcutaneous immune globulin administration

Additional speakers presenting their research on Newborn Screening for Combined Immune Deficiency:

Newborn Screening for SCID in New York State
Artemio M. Jongco III, MD, PhD, MPH
Fellow in Allergy and Immunology
North Shore-Long Island Jewish Health System

Newborn Screening for SCID: the Wisconsin Experience (2008 - 2011)
James Verbsky, MD, PhD
Assistant Professor of Pediatrics
Medical College of Wisconsin
Division of Asthma, Allergy and Immunology, and Rheumatology

This session is supported byCSL Behring
3:00 pm - 3:30 pm Break
3:30 pm - 5:30 pm T Cells: How Do They Handle Commitment?

Credit: 2 CME
Upon completion of this session, participants should be able to: apply translational medicine to autoimmune diseases based on CD6 targeted approaches; and have an understanding that a prolong lymphocyte depletion may not be required to induce a therapeutic effect in autoimmune disease patients.
3:30pm - 4:00pm Plasticity of Th Cells
John J. O'Shea, MD
NIH
4:00pm - 4:30pm Dual role of Retinoic acid in intestinal immunity
Bana Jabri, MD, PhD
University of Chicago
4:30pm - 4:45pm CD6 Targeted Immunotherapy Controls Inflammation in Autoimmune Diseases
Enrique Montero, MD, PhD
Center of Molecular Immunology
4:45pm - 5:00pm In Situ Detection of Islet Antigen-Specific CD8 T Cells in Insulitic Lesions of Type I Diabetes Patients
Matthias von Herrath, MD
La Jolla Institute for Allergy & Immunology
5:00pm - 5:15pm Correlation of a Blood Cell-Based Molecular Signature with Immunopathogenesis in Celiac Disease
Mitchell Garber
Alvine Pharmaceuticals Inc.
5:15pm - 5:30pm Generation of Regulatory Dendritic Cells for Graft-Versus-Host Disease Therapy from Older Healthy Donors and Bone Marrow Transplant Recipients Under Clinically Relevant Conditions
Sabrina Scroggins, BS
University of Iowa
5:30 pm - 6:00 pm CIS Business Meeting
5:30 pm - 7:30 pm Poster Reception

Saturday, May 21
6:30 am - 8:30 am Breakfast
7:00 am - 8:30 am The Patient, the Physician, and the Payor: A Multiperspective Look at the Challenges of Treating Primary Immunodeficiency Disease
7:00am Introduction and Objectives
Mark Ballow, MD (Co-Chair)
SUNY Buffalo
7:05am Dosing & Therapy Utilization
Elena E. Perez, MD, PhD (Co-Chair)
University of South Florida
All Children's Hospital

Mark Ballow, MD
SUNY Buffalo
7:25am Payor Issues From the Standpoint of the Patient, Physician, and Payor:
A panel discussion on issues related to formulary choices, sites of care, routes of administration, and insurance coverage
Ralph S. Shapiro, MD
Midwest Immunology Clinic

Marcia Boyle
Immune Deficiency Foundation
8:00am Advocacy Support: A discussion of local and national advocacy efforts to ensure that patients with PIDD are treated appropriately
Marcia Boyle
Ralph S. Shapiro, MD
Elena E. Perez, MD, PhD
8:25am Conclusions
Elena E. Perez, MD, PhD
Mark Ballow, MD

Session supported by Baxter
8:30 am - 10:45 am Immune Checkpoint Blockade as Cancer Therapy

Credit: 2.25 CME
Upon completion of this session, participants should be able to: understand the principles of immune regulation; and learn about the translation of new basic discoveries in cancer immunology, into effective cancer immunotherapies.
8:30am - 9:00am CTLA-4 Blockade
Jim Allison, MD, PhD
Memorial Sloan-Kettering Cancer Center
9:00am - 9:30am Implicating the ICOS/ICOSL Pathway as a Target for Cancer Immunotherapy
Padmanee Sharma, MD, PhD
MD Anderson Cancer Center
9:30am - 9:45am Induction of NKT Cell-Specific Immune Responses in Cancer Tissues after NKT Cell-Targeted Adoptive Immunotherapy
Kazuki Yamasaki, MD
Graduate School of Medicine, Chiba University
9:45am - 10:15am Adoptive Transfer of T cells
Carl June, MD
University of Pennsylvania
10:15am - 10:45am Anti-PD-1 in Clinical Trials
Suzanne Topalian, MD
Johns Hopkins University
10:45 am - 11:00 am Break
11:00 am - 12:30 pm Future Technologies / Sequencing

Credit: 1.5 CME
Upon completion of this session, participants should be able to: understand the role of anticytokine autoantibodies in immunodeficiency; recognize diseases commonly associated with anticytokine autoantibdodies; understand important characteristics of antibodies that may influence disease manifestations: titer, functionality, IgG subclass; and identify common infections associated with anti-IFN-g autoantibodies.
11:00am - 11:30am Timothy B. Niewold, MD
University of Chicago
11:30am - 12:00pm Restoring Immune Regulation in Human Autoimmune Disease: Peptide Vaccines and Stem Cell Transplants
Syamal Datta, MD
Northwestern University Feinberg School of Medicine
12:00pm - 12:15pm Mapping Immune Cell Signaling Network Responses using Single Cell Network Profiling in Peripheral Blood Mononuclear Cells from Healthy Donors: Defining "Normal"
Diane Longo, PhD
Nodality
12:15pm - 12:30pm Acquired Immunodeficiency due to Anti-Interferon-Gamma Autoantibodies in HIV Negative Asian Adults
Sarah Browne, MD
National Institutes of Allergy & Infectious Diseases, NIH
12:30 pm - 1:30 pm Lunch Break
1:30 pm - 3:00 pm Novel New Diagnostics

Credit: 1.5 CME
1:30pm - 2:00pm Use of Mass Spec Flow for Multi-Parameter Analysis
Erin Simonds, BS
Stanford University School of Medicine
2:00pm - 2:30pm Immune profiling by high-throughput sequencing of B and T cell receptors
Harlan Robins, PhD
Fred Hutchinson Cancer Research Center
2:30pm - 3:00pm Steven M. Holland, MD
National Institute of Allergy & Infectious Diseases, NIH
3:00 pm - 3:30 pm Break
3:30 pm - 5:30 pm B Cells: They Regulate Too, You Know

Credit: 1.75 CME
Upon completion of this session, participants should be able to: understand B cell biology in general; tolerance; immunosuppression; Rituximab; and autoimmunity.
3:30pm - 4:00pm Regulatory B Cells in Health and Disease
Claudia Mauri, PhD
UCL
4:00pm - 4:30pm Getting to the Center of the Germinal Center
Michel Nussenzweig, MD, PhD
The Rockefeller University
4:30pm - 4:45pm Generation of Autoantibodies in Dendritic Cell Specific Blimp-1 Deleted Mice
Sun Jung Kim, PhD
The Feinstein Institute for Medical Research
4:45pm - 5:15pm B Cell in CVID
Charlotte Cunningham-Rundles, MD, PhD
Mt. Sinai Medical Center
5:30 pm - 7:30 pm Poster Reception

Sunday, May 22
7:30 am - 8:30 am Breakfast
8:30 am - 10:30 am Innate Immunity, Finally Getting Some Respect

Credit: 2.25 CME
Upon completion of this session, participants should be able to: understand the basic mechanisms of innate immune activation; define the role of Toll like receptors in bacterial and parasitic infections; learn of the potential for microbial DNA to mediate serious compications of infection; learn of potential new therapies for fatal complications of plasmodial infections.
8:30am - 9:00am Monocytes and Macrophages in Atherosclerosis
Klaus Ley, MD
La Jolla Institute for Allergy & Immunology
9:00am - 9:30am Plasmacytoid Dendritic Cells at the Interface of Viral Control and Autoimmunity
Marco Colonna, MD
Washington University School of Medicine
9:30am - 10:00am The role of Innate lymphoid cells in influenza infection in the lung
Dale Umetsu, MD, PhD
Harvard Medical School
10:00am - 10:30am TLR Signaling
Douglas Golenbock, MD
University of Massachusetts
10:30am - 10:45am X-linked Hyper-IgM Patients Present Neutrophil Toll Like Receptor 2 Deficiency Resulting in Defective Respiratory Burst Response that can be Reversed by Exogenous IFN-gamma
Otavio Marques
Universidade de Sao Paulo
10:45 am - 11:00 am Break
11:00 am - 12:00 pm Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?
Jean-Laurent Casanova, MD, PhD
The Rockefeller University
Credit: 1 CME