2012 Annual Meeting: Primary Immune Deficiency Diseases North American Conference, May 17-20, 2012, Chicago, IL

Final Program

Please click the cover to the left to view the 2012 Annual Meeting Final Program

To view a web version of the the 2012 Annual Meeting program where you are able to review session schedules, browse the meeting by day or program and search for authors and titles, please visit http://cis.confex.com/cis/2012/webprogram/start.html Thursday, May 17
8:00am – 5:30pm	SITC Primer on Tumor Immunology & Cancer Immunotherapy™
8:00am – 5:30pm	AARDA Satellite: Sex, Gender & Autoimmunity through the Lifespan
8:00am – 5:30pm	PID School: Clinical Updates for the Practicing Immunologist
6:00pm – 7:00pm	Robert A. Good Opening Annual Meeting Lecture Moderator: Savita Pahwa, MD Speaker: Christoph Klein, MD Ludwig Maximilian University
7:00pm – 8:30pm	Annual Meeting Opening Reception

Friday, May 18
7:00 – 8:30am	Concurrent Breakfast Sessions Session 1: Controversies in Transplantation Hans Ochs, MD University of Washington James Casper, MD Medical College of Wisconsin Lisa H. Filipovich, MD Cincinnati Children's Hospital Session 2: Controversies in Ig Replacement Ralph Shapiro, MD Midwest Immunology Clinic Francisco (Tony) A. Bonilla, MD, PhD Children's Hospital Boston Efficiency of IgG Replacement Therapy in Patients with CVID: Correlations with Clinical Phenotype & Polymorphism of the Neonatal FC Receptor Eric Oksenhendler, Hospital Saint Louis Evaluation of Correlation between Dose & Clinical Outcomes in Subcutaneous Immunoglobulin Replacement Therapy Jordan Orange, University of Pennsylvania School of Medicine Session 3: Complexities of Newborn Screening Shigeaki Nonoyama, MD, PhD National Defense Medical College, Saitama, Japan Charlotte Cunningham-Rundles, MD, PhD Mt. Sinai Medical Center James Verbsky, MD, PhD Medical College of Wisconsin Luigi Notarangelo, MD Harvard Medical School A Universal Callibrator for TREC Testing Assists Newborn Screening for SCID & Studies of Immunoreconstitution Divya Punwani, University of California San Francisco
8:30 – 10:00am	Plenary: Combined Defects Alain Fischer, MD, PhD INSERM - Hospital Necker Clinical Presentation, Long-term Outcome & Therapeutic Management of DOCK8 Deficiency - An International Survey of 125 Patients Michael H. Albert, Dr. von Haunersches Kinderspital Dendritic Cells from X-Linked Hyper IgM Patients Present Impaired Responses to Candida Albicans and Paracoccidioides Brasiliensis that acan be Reversed by Exogenous Soluble CD40L Otavio Cabral Marques, University of Sao Paulo Caspase-8 Deficiency Manifesting as Adult-Onset Muti-Organ Granulomatous Disorder with Recurrent Infections Joao Bosco Oliveira, NIH
10:00 – 10:30am	Morning Break
10:30am – 12:00pm	Plenary: Wiskott Aldrich Jordan Orange, MD, PhD Children's Hospital of Philadelphia Pam Schwartzberg, MD, PhD National Human Genome Research Institute, NIH Reversion of WAS Gene Mutation: Does it Affect Immune Function & Clinical Phenotype? Qili Zhu, University of Washington School of Medicine Thrombotic Complications in GATA2 Deficiency Lauren A. Sanchez, NIAID, NIH
12:00 – 1:30pm	Poster Session Light snacks and refreshments provided
12:00 – 1:30pm	NIT/FIT Meet-and-Greet
1:30 – 3:00pm	Plenary: Novel Techniques in Immune Profiling Troy Torgerson, MD, PhD University of Washington Holden Maecker, PhD Stanford University Scott Boyd, PhD Stanford University Shigeaki Nonoyama, MD, PhD National Defense Medical College, Saitama, Japan
3:00 – 3:30pm	Afternoon Break
3:30 – 5:00pm	Concurrent Workshops Workshop 1: Immuno-suppressing the Immune Suppressed Ramsay Fuleihan, MD Northwestern University Jack Routes, MD Medical College of Wisconsin Steven M. Holland, MD NIAID, NIH Steven M. Holland, MD Workshop 2: Antibody Defects Jason Raasch, MD Midwest Immunology Clinic Javeed Akhter, MD Advocate Hospital Altered Specificity of IgM Responses due to Primary Immunodeficiency or Splenectomy Paul J. Maglione, Mt. Sinai School of Medicine The Sum of Initial IgG, IgA, & IgM, Viewed as a Percentage of the Lower Limit of Age-Adjusted Normal Values, is Predictive of Time to Normalization in Infants with Hypogammaglobulinemia RC Van Winkle, Thomas Jefferson University Workshop 3: Transplant: What is the Right Preparative Regimen? Morris Kletzel, MD Northwestern University Feinberg School of Medicine James Casper, MD Medical College of Wisconsin Allogeneic Hematopoietic Cell Transplantation for XIAP Deficiency: Survival Outcomes of 19 Patients Rebecca Marsh, Cincinnati Children's Hospital Medical Center Assessing the Role of Tissue Infiltrating Antigen Presenting Cells in Graft-versus-Host Disease through Two Photon Intravital Microscopy Christian Wysocki, Yale
5:00 – 6:00pm	Fred Rosen Lecture Raif Geha, MD Children's Hospital Boston
6:00 – 7:30pm	Reception & Poster Session

Saturday, May 19
7:00 – 8:30am	Concurrent Breakfast Sessions Session 1: Antimicrobials in Immune Defects Alexandra Freeman, MD NIAID, NIH William J. Muller Northwestern University Feinberg School of Medicine Amos Etzioni, MD Meyer Children's Hospital CMX001 as Therapy for Severe Adenovirus Infections in Immunocompromised Pediatric Patients: Single Center Experience in 6 Patients Michael Sean Grimley, Cincinnati Children's Hospital Medical Center Session 2: Hot Topics from the Registries Charlotte Cunningham-Rundles, MD, PhD Mt. Sinai Medical Center Kathleen Sullivan, MD, PhD Children’s Hospital of Philadelphia PIDD in a New University Clinic in Aguascalientes, Mexico, as part of the L-Project of the LASID: The First Months Aristoteles Alvarez-Cardona, Universidad Autonoma de Aguascalientes Diabetes and Cardiovascular Disease in p47phox-/-CGD Jennifer W. Leiding, NIAID, NIH Prevalence of PID: A Systematic Review Hillary S. Hernandez-Trujillo, Children's Hospital of Philadelphia CVID: Massachusetts General Hospital Cohort Outcomes & Analysis Lael M. Yonker, Massachusetts General Hospital Session 3: Resources for Teaching Primary Immune Deficiency Soma Jyonouchi, MD Children's Hospital of Philadelphia Shigeaki Nonoyama, MD, PhD National Defense Medical College, Saitama, Japan Evidence of Concomitant XLA & CGD in the same Patient Ramsay L. Fuleihan, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine Disseminated Histoplasmosis caused by IL 12RB1 Gene Mutations in Two Brazilian Siblings Ana Carla Augusto Moura Falcão, University of Pernambuco
8:30 – 10:00am	Plenary: Microbiome & Mucosal Interactions between immune development and viral respiratory illnesses in childhood James E. Gern, MD University of Wisconsin James Versalovic, MD Texas Children's Hospital Impaired Mast Cell Function Leads to Reduced Allergic Disease in AD-HIES Patients Andrea M. Siegel, NIAID, NIH Gut Immune Reconstitution in IPEX Syndrome after HSCT Eleonora Gambineri, Anna Meyer Children's Hospital, University of Florence
10:00 – 10:30 am	Morning Break
10:30am – 12:00pm	Plenary: Topic TBD Steven Holland, MD NIAID, NIH CIS/Baxter Award Recipients Lisa Forbes, MD Children's Hospital of Philadelphia Jolan Walter, MD, PhD Children's Hospital Boston Immature B Cells Preferentially Switch to IgE with Increased Direct Sμ to Sε Recombination Duane Wesemann, Harvard Medical School Invariant NKT Cells Mediate TCR- and Perforin-Dependent Cytotoxic Control of T-cell Lymphoma Hamid Bassiri, Children's Hospital of Philadelphia
12:00 – 12:30pm	CIS Business Meeting
12:30 – 1:30pm	Poster Session Light snacks and refreshments provided
12:30 – 1:30pm	CIS Past President's Luncheon
1:30 – 3:00pm	Concurrent Workshops Workshop 1: : Mutation & Lab Analysis in Primary Immune Deficiency Joao Bosco Oliveira, MD, PhD NIH Clinical Center Thomas A. Fleisher, MD National Institutes of Health Exome Sequencing Reveals a Pallidin Mutation in a Hermansky-Pudlak-Like Primary Immunodeficiency Syndrome Raffaele Badolato, University of Brescia DOCK8 Large Genomic Deletions & Abdominal Vasculitis in Children with Autosomal Recessive Hyper-IgE Syndrome Saul Oswaldo Lugo Reyes, National Institute of Pediatrics The Impact of TACI Mutations on Health & CVID Neil Romberg, Yale University School of Medicine Workshop 2: Autoimmunity and Immune Deficiency Talal Chatila, MD Children's Hospital Boston, Harvard Medical School James Verbsky, MD, PhD Medical College of Wisconsin SAP is Essential for the Establishment of Human B Cell Tolerance Laurence Menard, Yale University School of Medicine Titer, and not Avidity Determines Degree of Pathogenicity of Anti-IFNγ Autoantibodies in Mediating Immunodeficiency Sarah K. Browne, NIAID, NIH
3:00 – 3:30pm	Afternoon Break
3:30 – 4:30pm	Corporate Sponsored Symposium: Innovative Strategies for Diagnosing Primary Immune Deficiencies Preliminary Agenda 3:30pm Overview: Challenges in Screening & Diagnosing of Primary Immune Deficiencies Charlotte Cunningham-Rundles, MD, PhD (Chair) Mount Sinai School of Medicine 3:45pm Results From a Pilot Screening Program Jen Seda, MD Baxter Healthcare Corporation 4:00pm Where Do We Go From Here? James Verbsky, MD, PhD Medical College of Wisconsin 4:15pm Expert Panel Discussion and Q&A Francisco A. Bonilla, MD, PhD Children's Hospital Boston Ramsay Fuleihan, MD Northwestern University Daniel Suez, MD, FAAAAI University of Texas Southwestern 4:30pm Adjournment This session is made possible by
4:30 – 6:00pm	Corporate Sponsored CME Symposium: New Approaches to Immunoglobulin Therapy in Primary Immunodeficiency Disease 1.5 AMA PRA Category Credits™ Preliminary Agenda Welcome and Introduction Mark R. Stein, MD Allergy Associates of the Palm Beaches New Approaches to IgG Dosing Mark Ballow, MD SUNY Buffalo Practical Guidance in Using IGSC Ralph Shapiro, MD Midwest Immunology Clinic Looking Forward: Advances in Subcutaneous Delivery Mark R. Stein, MD Allergy Associates of the Palm Beaches Case Discussion and Q&A Learning Objectives: Following participation in this activity you should be able to: Describe advantages and disadvantages of the two principal forms of IgG administration used to manage complications of PIDD:intravenous (IGIV) and subcutaneous (IGSC) Assess studies supporting individualizing IgG dose levels to reduce infections and related complications of PIDD and their application to clinical practice Assess recommended approaches for the healthcare team and patients to optimize IGSC delivery Assess data on new IGSC therapies in development. Supported by an educational grant from
6:00 – 7:30pm	Reception & Poster Session

Sunday, May 20
7:00 – 8:30am	Concurrent Breakfast Sessions Session 1: Expanding Spectrum of Primary & Secondary Hemophagocytic Syndromes Edward M. Behrens, MD Children's Hospital of Philadelphia Kimberly Risma, MD, PhD Cincinnati Children's Hospital Medical Center The 253KB Inversion and 118 (-308) C>T Intronic Mutations in UNC13D are Common in Patients with FHL3 in North America Yaping Qian, Cincinnati Children's Hospital Medical Center Atypical Lymphoproliferative Syndrome Associated with STXBP2 Deficiency Zeynep Yesim Kucuk, Cincinnati Children's Hospital Medical Center Session 2: Gene & Other New Therapies Donald B. Kohn, MD UCLA Fabio Candotti, MD GMBB, NHGRI, NIH Upregulation of TRIC Improves STAT3 Activity in AD HIES Claire E. Bocchini, Baylor College of Medicine & Texas Children's Hospital Abatacept as a Novel Therapeutic Option for GLILD & Other Autoimmune Features in Patients with CVID Michael B. Jordan, Cincinnati Children's Hospital Medical Center Session 3: Practical Diagnostic Flow Cytometry & Multiparameter Research Tools Thomas A. Fleisher, MD National Institutes of Health Joao Bosco Oliveira, MD, PhD NIH Clinical Center Michael R. Betts, PhD University of Pennsylvania An Improved Flow-based Screening Method for SCID Stephanie Jade Anover-Sombke, University of Washington
8:30 – 10:30am	Plenary: The Complexities of CVID Charlotte Cunningham-Rundles, MD, PhD Mt. Sinai Medical Center Joshua Milner, MD NIAID, NIH John Routes, MD Medical College of Wisconsin Mutations in LRBA are Associated with a Syndrome of Immune Deficiency & Autoimmunity Gabriela Lopez-Herrera, National Institute of Pediatrics Chronic ER Stress as a Cause for Deficient Proliferation & Spontaneous Apoptosis in CVID Maristela M. de Camargo, University of São Paulo
10:30 – 10:45am	Break
10:45am – 11:30am	Plenary: Closing Keynote Luigi Notarangelo, MD Children's Hospital, Harvard Medical School

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Final Program

Please click the cover to the left to view the 2012 Annual Meeting Final Program